Project B1 - Modulation of neural mechanisms underlying crossmodal predictions

PIs: Prof. Dr. Andreas Engel, Prof. Dr. Dan Zhang

Using MEG and EEG, Project B1 will investigate the dynamics of neural oscillations involved in uni- and crossmodal temporal predictions. Recordings in healthy participants will be combined with studies in patients with Parkinson’s disease (PD) who have impairments in updating stimulus predictions and in judging event timing. We will modulate the neural mechanisms underlying temporal predictions by manipulation of relevant sensory cues and by neurostimulation approaches. These will include transcranial alternating current stimulation (tACS) in healthy participants and deep brain stimulation (DBS) in the patients. Furthermore, we will implement ensemble oscillator models to account for the observed modulation of uni- and crossmodal predictions.